Zopiclone (Imovane) is indicated for the short-term therapy and symptomatic aid of insomnia characterized by issue in falling asleep, frequent nocturnal awakenings and/or early morning awakenings.
Treatment with zopiclone should normally not exceed 7-10 consecutive days. Use for more than 2-3 consecutive weeks requires complete re-evaluation of the affected person. Prescriptions for zopiclone ought to be written for short-term use (7-10 days) and it shouldn’t be prescribed in portions exceeding a 1-month supply.
The use of hypnotics ought to be restricted for insomnia where disturbed sleep results in impaired daytime functioning.
Dosage and administration:
Imovane should solely be taken when you are ready to get a full evening’s sleep (7 to 8 hours) earlier than you should be lively again.
The standard adult dose of zopiclone is one tablet simply before you go to mattress.
This medicine ought to be taken in a single consumption and never readministered throughout the same evening.
If you’re over sixty five years of age the dose is half a pill taken simply before you go to mattress.
If you might have a liver or kidney problem, the standard beneficial dose is half a pill taken just earlier than you go to bed.
Overdosage:
Signs and signs:
Overdose by zopiclone pills is normally manifested by various degrees of central nervous system melancholy ranging from drowsiness to coma based on the quantity ingested. In mild cases, signs embody drowsiness, confusion, and lethargy; in additional extreme circumstances, signs may include ataxia, hypotonia, hypotension, methaemoglobinaemia, respiratory despair, and coma. Overdose should not be life threatening except combined with other CNS depressants, together with alcohol. Other threat components, such as the presence of concomitant illness and the debilitated state of the affected person, may contribute to the severity of symptoms and really rarely may end up in deadly consequence.
In voluntary or unintended cases of zopiclone overdosage involving doses as a lot as 340 mg, the principal effects reported had been extended sleep, drowsiness, lethargy and ataxia.
Recommended therapy:
Symptomatic and supportive therapy in sufficient medical setting is really helpful, attention must be paid to respiratory and cardiovascular features. Gastric lavage or activated charcoal is simply useful when carried out soon after ingestion.
Hemodialysis is of no worth because of the large volume of distribution of zopiclone. Flumazenil may be a useful antidote; nevertheless, flumazenil administration may contribute to the looks of neurological signs (agitation, nervousness, convulsionsand emotional lability). Intravenous fluids must be administered as needed.
